Technology
Cellbricks‘ proprietary light-based biofabrication system introduces a novel and automated approach to producing human tissue therapeutics – enabling scalability and speed beyond other methods – supported by AI-powered tissue engineering.
Step 1: Material Loading
Therapeutic cells + customized biomaterials loaded into biofabrication system.
Step 2: Tissue Production
Biofabrication technology, enhanced by AI-powered tissue engineering, combines cells and biomaterials into human tissue.
Step 3: Functional Tissue
Within minutes immune-compatible, biological functional tissue therapeutics are produced.
Step 4: Function Recovery
Application of tissue therapeutics to the patient to restore soft tissue defects or organ function.
Key Advantages
Our technology meets all critical requirements for industrial-scale manufacturing of human tissue, ensuring both excellent scalability and tissue viability. Moreover, we have the entire value chain in-house. This end-to-end approach allows us to deliver consistent quality, full process control, and rapid translation.
Scalability
Our process excels at producing large-scale tissues – both in volume and size – while maintaining precise bioarchitecture, making it one of the most scalable biofabrication systems available.
Tissue Viability
Our process is highly cell-friendly, using tailor-made biomaterials and avoiding shear stress on the cells – enabling exceptional cell viability across all cell types.
Value Chain In-house
Cellbricks has extensive expertise in the four key domains for manufacturing of tissue therapeutics:
1) Proprietary biofabrication tech.
2) Tailor-made biomaterials.
3) Tissue engineering expertise.
4) AI-powered tissue engineering.
AI-powered Tissue Engineering
Our software generates a detailed building plan of the tissue therapeutic incorporating the final bioarchitectures using deep learning–based process control and AI-driven fluid dynamics. These building plans guide the biofabrication system in assembling therapeutic cells and biomaterials into functional, human tissues. Powerful image recognition algorithms ensure optimal fabrication quality and process integrity, while 3D-fluid simulations and adaptive flow optimization lead to increased tissue viability and reliability.
Key Advantages
Our technology is designed to meet all critical requirements for industrial-scale manufacturing of human tissue, ensuring both high tissue viability and scalability. Moreover, we have the entire platform in-house. This end-to-end approach allows us to deliver consistent quality, full process control, and rapid translational potential.
Tissue Viability
Our process is highly cell-friendly, as it applies no shear stress and uses tailor-made bioinks to achieve exceptional cell viability across all cell types.
Scalability
Our process enables large-volume production by combining high speed printing with the ability to handle complex structures, resulting in one of the most scalable manufacturing platforms available.
In-house Platform
Routed on deep tech innovation Cellbricks owns the three key domains for manufacturing of tissue therapeutics:
1) Proprietary printing technology.
2) Tailor-made bioinks.
3) Tissue engineering expertise.
Technology Behind The Biofabrication Process
Step 1: Design
A digital building plan of the desired biological structure is created recapitulating the tissue’s bioarchitecture – cell types, extracellular matrix and vascular network and more. The final tissue design is sliced, like an MRI scan, and send to the biofabrication system.
Step 2: Formulation
Tailor made biomaterial – the extracellular matrix (ECM) – and therapeutic cells are prepared and mixed. The liquid cell-laden biomaterial is loaded into transparent vats that sit above a light source in the biofabrication system.
Step 3: Projection
A high-resolution blue light projector sits underneath the vat. From above a build plate dips in the vat. The projector underneath the vat selectively projects specific „slices of the digital building plan“ through the bottom to cure certain sections of the biomaterial. The biomaterial solidifies on the build plate.
Step 4: Layering
The build plate is dipped into the next vath containing different cells. Another slice of the tissue design is exposed. Layer by layer, the final tissue is build.
Step 5: Completion
Within minutes large volume human tissue is created consisting of an extracellular matrix and millions of embedded therapeutic cells. Ready for the patient.
